Fusion is a twist by designer Reinhard Staupe on his own Speed/Blink. The card deck consists of 72 cards with each card having a number (1-6), a letter (one of six, which spell out "fusion"), and a color on that letter (one of six). Three rule cards are placed face-up, with one card from the deck placed next to each rule to start a pile.
The remaining cards are dealt evenly among the players, and each player draws the top three cards in hand. Then they simultaneously play cards from their hands onto the three piles, following the rules for play and refilling their hands to three cards whenever they desire. The rules for playing:
• "=" – The card being played must match the color or letter of the card being covered.
• "+1/-1" – The number on the card being played must be one higher or one lower than the card being covered.
• "≠" – The card being played cannot match the number, color or letter of the card being covered.
The first player to run out of cards wins the game.