Game description from the publisher:
The ancient evil known as Doom has decided to make a change. In this new world of Numenera, Doom has manifested as an intelligent virus that controls its hosts. The infected are known as "Doomladen" and they know each other regardless of a host's external form. They are lead by powerful beings with strange relics – the Thunderstones – and once again you must defeat them to save the world.
In the deck-building game Thunderstone Advance: Numenera, which can be played on its own or combined with other Thunderstone sets, you build a party of heroes to defeat the Thunderstone Bearers. The "Doomladen" mechanism introduced in this game unites various monster groups against you, and new Setting cards take you into the environment of Monte Cook's Numenera RPG.