This game is set in H.P. Lovecraft's fictional Miskatonic University. The two players take on the roles of either the Cultists out to wake one of the elder gods, or the Investigators trying to get to the bottom of it and save humanity.
From the designer, on the website:
...this is an update of a very simple game I designed years ago and gave out a conventions to people who play-tested Arkham Horror and my more robust game designs. It is meant to be simple and in no way is comparable to Arkham Horror or Trail of the Brotherhood, but in it's own right is fun and there is a strategy to playing the game. Lastly like Lovecraft stories, the magic of this game is in the imaginations of the viewers. With imagination it is a fun little game.