Raffaello Sanzio da Urbino (c. April-March, 1483 - April 6, 1520) was a famous Italian painter and architect of the High Renaissance. Raphael, Michelangelo, and Leonardo da Vinci form the traditional trinity of great masters of this period.
A version of his 1506 painting of Angelo Doni has been used as cover art for the board games Il Principe and Oltre Mare. http://en.wikipedia.org/wiki/Portrait_of_Agnolo_Doni
This artist is one of the Famous (non-game) Artists on the Geek.