From the Cheapass Games web page (http://cheapass.com/products/boardgames/cag001.html):
Why do all mystery games start just after all the fun is over?

Welcome to the J. Robert Lucky mansion, a sprawling country estate just ten miles north of nowhere. It's a fine country home, chock full of unusual weapons, good hiding places, and craven killers. Killers like you.

The object? Kill Doctor Lucky. Find a weapon, track the old man down, and do him in. The obstacles? For one thing, all of your friends would rather do it first. For another, Doctor Lucky is aptly named. You would think that after being stabbed, hung, poisoned, and poked in the eye, the Old Doctor would just lie down and accept his fate. But he's got more lives than Rasputin, and an uncanny knack for dodging your best traps.

Stick to it. Persevere. The Doctor's luck won't last forever. Before the night is over, someone is going to kill Doctor Lucky. And it might as well be you.

Game Synopsis: Everyone starts in the Drawing room, and everyone wants to kill Doctor Lucky. Players move around the mansion looking for weapons and trying to catch the old man alone. Trying to kill the Doctor is pretty easy, but every other player can play Failure cards to stop you. Doctor Lucky's luck runs out eventually, though, and you just hope you can catch him when it does.

Director's Cut: This new edition of Kill Doctor Lucky features a second game board (modified from the "unnamed house" we used to offer as an expansion), improved wit on the Failure cards, new game variants (most of which have appeared at one time or another on this web site) and a commentary track by designer James Ernest. It's everything you always wanted in a game, and more.