Quest items are cards with powerful effects that, once obtained, are available to all players at any time.
You will be able to earn them in many ways during your peregrinations. Hope (equivalent to "experience points"), for example, is a Quest Item card, but there are many more that you will discover for yourself as you play.
These cards are normally placed on the 'Quest Item' divider (laid flat on the table during play) and behind the same divider when you save the game.
If you prefer to keep everything organized and stored together, you can now place all of your group’s Quest item cards in this handy binder. The cards will fit with or without sleeves.
—description from the publisher