Pueblo is fundamentally an abstract game, in which you're trying to score as few points as possible. On your turn, you place one of your building blocks on the board (you have blocks in your own colour, and some 'neutral' blocks) and then move the 'Chieftain' pawn up to three spaces around the track on the edge of the board. The dude then looks along the row where he lands - if he can see any blocks of your colour, you score points depending on how high off the ground the block is. There is some additional scoring when the Chieftain lands on a corner square, but that's a detail you don't need to know here.
It's a really good game; it takes about 45 minutes to play, it's different and it looks great.
Our first game was 3-player and we used the standard rules: Dan 41, Stuart 55, Me 62
Our second game was 4-player and we included the four 'sacred site' markers which remove areas of the board from play: Me 35, Stuart 55, Hugh 56, Dan 63
Our game of The Climbers was odd in that it finished fairly quickly. We got to a point where Dan could move one of the two large neutral blocks in the centre of the tower, which resulted in none of us being able to climb any higher.
Final positions: Dan (got to the top first), Me, Stuart