This setting covers two distinct sets of books that, although geographically distinct, are close enough in time that there can be interactions between them:
The World of Darkness setting of 1830 is a dark mirror of the real world American Old West: the "Savage West" rather than the "Wild West". Settlers encroach more and more on the traditional lands of the natives, and these tensions are reflected in the clashes between European and Native American werewolf tribes. And a threat to all is the powerful Bane spirit called the Storm Eater that tears apart all in its path.
The Gothic Victorian period of the World of Darkness runs from 1880 (the founding of the Hermetic Order of the Golden Dawn) to 1897 (the arrival of Dracula in London). This time of cultured society and secret cabals is rife with possibilities for the political machinations of the Kindred, the vampires that hide amongst and attempt to sway humanity. The setting did not develop far as only three books were published before the old World of Darkness was discontinued.