Li Mei debuted in Mortal Kombat: Deadly Alliance as an Outworld warrior whose village was enslaved by Shang Tsung and Quan Chi. Her people were forced to build a temple from which the Deadly Alliance would summon the Soulnado. She attempted to win her village's freedom in a tournament hosted by Shang Tsung, but was betrayed. Her soul was subsequently stolen and placed in one of the Dragon King Onaga's soldiers.
Bo' Rai Cho saved her soul and trained her so that she would join the Forces of Light in the final Battle of Armageddon. Although she was killed in that battle by Hotaru's naginato, Li Mei was brought back to life (along with all of the other warriors who perished) by Raiden's resetting of the timeline. She made a brief appearance in the story mode of Mortal Kombat X, wherein Li Mei and her fellow villagers sought sanctuary in Earthrealm to escape the civil war raging between Kotal Kahn and Mileena. It was she who informed the Special Forces of Kano (Mortal Kombat)'s return to Earthrealm, and Raiden of Mileena's use of the Amulet of Shinnok.